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ORIGINAL ARTICLE
Year : 2022  |  Volume : 66  |  Issue : 5  |  Page : 17-21

Retrospective observational study to compare Xpert MTB/RIF assay with other diagnostic tests in lymph node tuberculosis

Nithya Haridas1, Asmita Mehta2, Akhilesh Kunoor2, Sadia Khan3
1 Associate Professor, Amrita Institute of Medical Sciences, Amrita Vishwa Vidya Peetham, Kochi, Kerala, India
2 Professor, Department of Respiratory Medicine, Amrita Institute of Medical Sciences, Amrita Vishwa Vidya Peetham, Kochi, Kerala, India
3 Associate Professor, Department of Microbiology, Amrita Institute of Medical Sciences, Amrita Vishwa Vidya Peetham, Kochi, Kerala, India

Correspondence Address:
Nithya Haridas
Guddy's, Chittayil House, Vaduthala, Kochi, Kerala,
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/ijph.ijph_1083_22

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Background: Lymph node tuberculosis (TB) is the most common form of extrapulmonary TB in India. Standards for TB care in India recommend microscopy/culture/CBNAAT/molecular test/histopathology examination and drug sensitivity testing on appropriate specimens from the presumed sites of involvement for all patients with presumptive extrapulmonary TB. Objectives: To analyze the utility of Xpert MTB/Rif assay in lymph node TB. Methods: All patients who underwent lymph node sampling between July 2014 and June 2017 and for whom Xpert MTB/Rif assay was done were included. Demographic profile, Xpert MTB/Rif assay result, histopathology/cytology findings, smear acid-fast bacillus (AFB), and AFB culture results were noted. A composite reference score (CRS) was made. Results: Xpert MTB/Rif assay was positive in 63 of the 81 patients. Xpert had a sensitivity of 82.14% and specificity of 86.18%when compared against AFB culture and 75.61% and 98.97% when compared against CRS. Conclusion: Xpert MTB/Rif assay is a valuable test for rapid diagnosis of lymph node TB.


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