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Year : 2022  |  Volume : 66  |  Issue : 4  |  Page : 512-515

Significance of Laboratory Markers in Predicting the Severity of COVID-19 in the Central Reserve Police Force Front-line Workers with a Review of Literature

1 Specialist Medical Officer, Department of Pathology and Laboratory Medicine, Composite Hospital, CRPF, Hyderabad, Telangana, India
2 Medical Officer, Department of Medicine, Composite Hospital, CRPF, Hyderabad, Telangana, India
3 Specialist Medical Officer, Department of Obstetrics and Gynecology, Composite Hospital, CRPF, Hyderabad, Telangana, India

Correspondence Address:
C H Krishna Reddy
Matrusri Nagar, Hyderabad, Telangana
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ijph.ijph_1470_21

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COVID-19 disease has variable clinical presentations, ranging from asymptomatic to mild symptoms to severe manifestation with pneumonia, acute respiratory distress syndrome, septic shock, disseminated intravascular coagulation, and/or multiple organ failure. The real-time reverse transcription–polymerase chain reaction is gold standard test for severe acute respiratory syndrome-coronavirus-2 detection. In the present study, we aimed to predict the significance of various hematological and biochemical markers for early identification of complications and assessing the severity of the disease. A total of cases were divided into two study groups, namely, severe and nonsevere based on clinical presentation. Out of 210 cases, 186 (88.5%) cases were nonsevere and 24 (11.5%) cases were severe. Among various hematological and biochemical markers studied, hemoglobin, total leukocyte count, neutrophil count, lymphocyte count, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio, albumin, lactate dehydrogenase, C-reactive protein, ferritin, D-dimer, and interleukin-6 are found to have P < 0.05 and significantly correlated with the severity of disease.

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