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Year : 1994  |  Volume : 38  |  Issue : 1  |  Page : 3-7

Perinatal mortality in eclampsia in relation to drug therapy.

Department of Pediatrics, R.G. Kar Medical College, Calcutta

Correspondence Address:
N Chaudhuri
Department of Pediatrics, R.G. Kar Medical College, Calcutta

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Source of Support: None, Conflict of Interest: None

PMID: 7883311

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Fifty-nine babies were born to eclamptic mothers among 7500 deliveries giving incidence of occurrence of 0.77 percent. The perinatal mortality in eclamptic babies was 32.7%, whereas the total perinatal mortality rate amongst all the deliveries was 10.5%. The mothers were treated within Group I--diazepam, Group II i chlorpromazine (largactil), phenargan and diazepam and Group III--largactil, phethidine and phenargan. The mortality rate was 23.8%, 18.8% and 66.6% respectively. The highest number of still-born i.e. six out of 8 occurred in Group III. Hundred percent still-born was noted in 28-32 weeks of gestation and birth weight less than 1.5 kg irrespective of drug regimes. Iargactil potentiates the respiratory depressant effect of pethidine and may cause high rate of still-birth and death after birth.

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