Users Online: 197 Home Print this page Email this page Small font sizeDefault font sizeIncrease font size
 

 

Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
     
ORIGINAL ARTICLE
Year : 2011  |  Volume : 55  |  Issue : 1  |  Page : 14-21

Risk factors associated with MDR-TB at the onset of therapy among new cases registered with the RNTCP in Mumbai, India


1 Research Officer, Foundation for Research in Community Health, Pune, India
2 Research Associate, Foundation for Medical Research, Mumbai, India
3 Ph.D. Student, Foundation for Medical Research, Mumbai, India
4 Director, Foundation for Research in Community Health, Pune and Foundation for Medical Research, Mumbai, India

Correspondence Address:
Sachin R Atre
Research Officer, Foundation for Research in Community Health, 85, 3 and 4 Trimiti B Apt. Pune
India
Login to access the Email id

Source of Support: The Wellcome Trust, UK, by CRIG Grant #GR073138MA, Conflict of Interest: None


DOI: 10.4103/0019-557X.82536

Rights and Permissions

Background: Multidrug - resistant TB (MDR - TB) has emerged as a major threat to global TB control efforts in recent years. Facilities for its diagnosis and treatment are limited in many high - burden countries, including India. In hyper - endemic areas like Mumbai, screening for newly diagnosed cases at a higher risk of acquiring MDR - TB is necessary, for initiating appropriate and timely treatment, to prevent its further spread. Objective: To assess risk factors associated with MDR - TB among Category I, new sputum smear-positive cases, at the onset of therapy. Materials and Methods: The study applied an unmatched case - control design for 514 patients (106 cases with MDR - TB strains and 408 controls with non - MDR - TB strains). The patients were registered with the Revised National Tuberculosis Control Program (RNTCP) in four selected wards of Mumbai during April 2004 - January 2007. Data were collected through semi - structured interviews and drug susceptibility test results. Results: Multivariate analysis indicated that infection with the Beijing strain (OR = 3.06; 95% C.I. = 1.12 - 8.38; P = 0.029) and female gender (OR = 1.68; 95% C.I. = 1.02 - 2.87; P = 0.042) were significant predictors of MDR-TB at the onset of therapy. Conclusion: The study provides a starting point to further examine the usefulness of these risk factors as screening tools in identifying individuals with MDR-TB, in settings where diagnostic and treatment facilities for MDR-TB are limited.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed11820    
    Printed125    
    Emailed3    
    PDF Downloaded1164    
    Comments [Add]    
    Cited by others 3    

Recommend this journal